NOT KNOWN FACTS ABOUT PROMETHAZINE WITH CODEINE

Carcinogenicity studies have been done with codeine. Two-yr research in F344/N rats and B6C3F1 mice had been performed to evaluate the carcinogenic opportunity of codeine. No proof of tumorigenicity was noticed in male and woman rats at codeine dietary doses up to 70 and eighty mg/kg/day (approximately comparable to 15 and 20 instances, the MRHD ov